Vidalista 80 Mg Tadalafil is one of the most popular ED and impotence treatments, with up to 70 percent of men regaining sexual function. While tadalafil is best known for its effectiveness against psychogenic impotence, it is also used to treat other types of ED. Men with conditions like diabetes, prostate cancer, and blood vessel problems are often effective candidates.
PDE-5 inhibitors
The PDE-5 inhibitors, like tadalafil, work by blocking the enzyme responsible for regulating cGMP, a hormone that relaxes smooth muscle tissue and regulates blood flow. By inhibiting this enzyme, PDE5 inhibitors can improve erectile function in as many as 70% of men. Other indications for the PDE-5 inhibitors include blood vessel disorders, diabetes, and prostate cancer.
Tadalafil was the third PDE5I approve by the FDA for treating erectile dysfunction (ED). It was well tolerate and has been found to improve erectile function across a broad age and disease range. However, there have been some concerns about tadalafil’s cross-reactivity with PDE11, so patients should be aware of this potential issue.
In the past, many treatments for ED have been ineffective and associated with numerous side effects. Several of these drugs were relatively invasive, and the most successful were penile vacuum pumps, intracorporeal injections, and penile prosthetics. However, many men still suffered from an inability to achieve an erection despite their efforts to improve their erectile function.
A clinical trial conducted by Rubio-Aurioles et al. found that tadalafil was superior to sildenafil, and resulted in a higher clinical response rate for all three PDE5Is compared to placebo. It was also found to improve the quality of erection in about half of the non-responders.
Shorter half-life
Although the shorter half-life of tadalafil may sound like a drawback, this new drug has a number of advantages that make it a popular choice for ED treatment. For example, the drug produces erections long enough to be use for intercourse. Compared to other medications, tadalafil lasts for about half as long, allowing for more efficient treatment.
In addition to its longer half-life, tadalafil is more effective than vardenafil in treating ED. Studies have demonstrate that this drug is highly effective in treating difficult-to-treat cases, including ED that is associate with diabetes, prostate cancer treatments, or prostate cancer. In addition, it has been shown to be safe for many patients.
Tadalafil is metaboliz extensively by CYP3A4 enzymes. The main circulating metabolite, methyl catechol, is excrete in the urine and feces and is not expecte to have pharmacological activity at its present concentrations. Its elimination is not impede by hemodialysis, although it may have a limite effect on the absorption of the drug.
In a randomize crossover trial, 100 couples with a male partner with ED were randomly assigne to take tadalafil or sildenafil for 12 weeks. Then, they were randomly assigne to the alternate treatment for 12 weeks. In both trials, men and their partners completed SEP diaries. The results showe that tadalafil was preferre by 79.2% of the couples and by 15.6% of the female partners.
Shorter onset of action
Tadalafil is a selective phosphodiesterase-5 inhibitor (SPEA) with several downstream effects on the body. These effects include vasculogenic, neurogenic, and psychogenic responses. It is the only FDA-approve medication to effectively treat both ED and impotence. The shortest onset of action enables the drug to work quickly, restoring sexual function for up to 70 percent of patients.
Tadalafil is an orally administere erectile dysfunction medication with a short onset of action. Tadalafil has been approve for the treatment of erectile dysfunction and benign prostatic hyperplasia, and its use was expande by the FDA in November 2007. Its short onset of action is one of its main advantages, providing a steady serum concentration even at low doses.
In healthy male volunteers, tadalafil exposure increases proportionally with dose. After a single oral dose of 20 mg, exposure is 1.6 times higher than after a single-dose study. In contrast, exposure to the drug is not affecte by the intake of food, as the pharmacokinetics of tadalafil were studie in subjects with no underlying medical conditions or diabetes.
In recent studies, Vidalista Professional mg has shown efficacy in treating men with erectile dysfunction and BPH. It also relieves symptoms of BPH and lowers urinary tract diseases. Tadalafil is also effective in treating impotence and symptoms associated with benign prostatic hyperplasia. However, the longer the treatment, the longer the duration of the effect.
